Objective: Population-based cancer registration data were used to analyze the epidemiology and trend of malignant mesothelioma in China, and the result would provide basic data for its prevention and control.Methods: Malignant mesothelioma data in 2013 were retrieved from the database of National Cancer Registry.Malignant mesothelioma incidence and mortality were estimated using age-specific rate by urban/rural and gender according to the national population in 2013. Malignant mesothelioma data from 22 cancer registries were used for trend analysis during 2000–2013.Results: It is estimated that there were 2,041 new malignant mesothelioma cases and 1,659 malignant mesothelioma deaths occurred in 2013. The crude incidence rate in China were 1.50/106(males 1.67/106, females1.32/106), age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 1.03/106 and 1.02/106, respectively. The crude mortality rate in China was 1.22/106(males 1.67/106, females 1.32/106), age-standardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were 0.83/106 and 0.81/106, respectively. There was an increasing trend of incidence rate for malignant mesothelioma in registration areas of China during 2000–2013 with annual percentage change(APC) of 2.5% [95% confidence interval(95% CI): 0.6%–4.5%]. After age standardization, no significant differences were observed. No matter for crude mortality rates or age-standardized mortality rates, no significant differences were observed during 2000–2013.Conclusions: Malignant mesothelioma is the major occupational and environmental neoplasm associated with asbestos exposure. The increasing incidence trend suggests that more attention should be paid on this disease. Objective: Population-based cancer registration data were used to analyze the epidemiology and trend of malignant mesothelioma in China, and the result would provide basic data for its prevention and control. Methods: Malignant mesothelioma data in 2013 were retrieved from the database of National Cancer Registry. Malignant mesothelioma incidence and mortality were estimated using age-specific rate by urban / rural and gender according to the national population in 2013. Malignant mesothelioma data from 22 cancer registries were used for trend analysis during 2000-2013. Results: It is estimated that there were 2,041 new malignant mesothelioma cases and 1,659 malignant mesothelioma deaths occurred in 2013. The crude incidence rate in China was 1.50 / 106 (males 1.67 / 106, females 1.32 / 106) ASIRC) and by world standard population (ASIRW) were 1.03 / 106 and 1.02 / 106, respectively. The crude mortality rate in China was 1.22 / 106 (males 1.67 / 106, females 1.32 / 106), age-standardized mortality rates by Chinese standard population (ASMRC) and by world standard population (ASMRW) were 0.83 / 106 and 0.81 / 106, respectively. There was an increasing trend of incidence rate for malignant mesothelioma in registration areas of China during 2000-2013 with annual percentage change (APC) of 2.5% [95% confidence interval (95% CI): 0.6% -4.5%]. After age standardization, no significant differences were observed. matter for crude mortality rates or age-standardized mortality rates, no significant differences were observed during 2000-2013. Conclusions: Malignant mesothelioma is the major occupational and environmental neoplasm associated with asbestos exposure. The increasing incidence trend suggests that more attention should be paid on this disease.