第三代先锋霉素类具有广谱、高效、低毒的特点,国外较多用于新生儿,本文主要叙述头孢氨噻肟(Cefotaxin,CTX)、头孢三嗪噻肟(Ceftriaxone,CTRX)和头孢去甲噻肟(Cefizoxime,CZX)在临床应用的某些问题。临床药效学CTX是一种新型第三代先锋霉素,它的甲氧亚胺键对抗菌活力起重大作用,主要取决于:(1)与青霉素结合蛋白的亲和性;(2)对β-内酰胺酶的稳定性;(3)对细胞壁的渗透性。本品对革兰氏阳性菌与第一代头孢菌素近似或较弱,而对许多革兰 The third generation of cephalosporins has the characteristics of broad spectrum, high efficiency and low toxicity. Most of them are used in newborns in foreign countries. Cefotaxin (CTX), ceftriaxone (CTRX) and cefotaxime Some problems of clinical application of Cefizoxime (CZX). Clinical Pharmacodynamics CTX is a novel third-generation cephalosporin that plays a major role in antibacterial activity depending on: (1) its affinity for penicillin-binding proteins; (2) β-lactamase stability; (3) permeability to the cell wall. This product is Gram-positive bacteria with first-generation cephalosporins similar or weaker, while for many Gram