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目的探讨高龄老年男性患者血清尿酸(SUA)水平与下肢动脉粥样硬化性疾病(LEAD)的关系。方法选择362例高龄老年男性患者,根据有无高尿酸血症对患者进行分组:高尿酸血症组(76例)及SUA正常组(286例)。进行体格检查,并询问病史,取血行肝功能、肾功能、血糖、血脂、SUA、糖化血红蛋白(HbAlc)、C反应蛋白(CRP)等检测,同时用彩色多普勒超声对患者下肢动脉血管进行检查,分析SUA水平与下肢血管病变发生的相关性。结果 (1)高尿酸血症组体质指数(BMI)、血尿素氮(BUN)、血肌酐(Scr)、三酰甘油(TG)及CRP均明显高于SUA正常组(P均<0.01),HbAlc及高密度脂蛋白胆固醇(HDL-C)显著低于SUA正常组(P均<0.01),且高血压、糖尿病及糖耐量异常、脑卒中、超重或肥胖、肾功能不全等疾病的发生率亦高于SUA正常组(P均<0.01)。(2)高尿酸血症组LEAD的发生率为39.47%,明显高于SUA正常组的28.32%(P<0.01),且下肢动脉直径狭窄程度随着SUA水平的升高而加重。(3)Logistic多元回归分析显示,SUA、TG、高血压、糖代谢异常为高龄老年男性患者发生LEAD的危险因素。结论高龄老年男性患者SUA水平升高与LEAD的发生、发展密切相关,可认为SUA是高龄老年男性患者发生LEAD的独立危险因素。
Objective To investigate the relationship between serum uric acid (SUA) levels and lower extremity atherosclerotic disease (LEAD) in elderly elder male patients. Methods A total of 362 elderly male patients were enrolled. Patients were divided into two groups according to whether there was hyperuricemia: hyperuricemia group (76 cases) and SUA normal group (286 cases). The physical examination was performed and the medical history was taken. Blood samples were collected for liver function, renal function, blood glucose, blood lipid, SUA, HbAlc and C-reactive protein (CRP). The color Doppler echocardiography Check and analyze the correlation between SUA level and the occurrence of lower extremity vascular lesions. Results The body mass index (BMI), blood urea nitrogen (BUN), serum creatinine (Scr), triglyceride (TG) and CRP in hyperuricemia group were significantly higher than those in normal SUA group (all P <0.01) HbAlc and HDL-C were significantly lower than those in normal SUA group (all P <0.01), and the incidence of hypertension, diabetes and impaired glucose tolerance, stroke, overweight or obesity, renal insufficiency and other diseases Also higher than normal SUA group (all P <0.01). (2) The incidence of LEAD in hyperuricemia group was 39.47%, which was significantly higher than that in normal SUA group (28.32%, P <0.01). The degree of arterial stenosis of lower extremity was increased with the increase of SUA level. (3) Logistic multivariate regression analysis showed that SUA, TG, hypertension and abnormal glucose metabolism were the risk factors for LEAD in elderly and elderly men. CONCLUSIONS: The elevated SUA levels in elderly male patients are closely related to the occurrence and development of LEAD. SUA is considered as an independent risk factor for LEAD in elderly and elderly male patients.