二磷酸盐能够增加骨密度(BMD),与激素替代疗法(HRT)一样可用于治疗绝经后妇女的骨质疏松症,尤其适用于不愿或不适于HRT者。临床上将HRT与二磷酸盐合用既能控制绝经症状又能预防骨折。利塞磷酸盐(Risedronate)是一有效的吡啶二磷酸盐,具有缓解骨Paget病、降低骨转换、增加骨密度、减少骨折等作用。作者探讨了绝经后妇女 Bisphosphonates increase bone mineral density (BMD) and are as useful as hormone replacement therapy (HRT) in the treatment of osteoporosis in postmenopausal women, especially those who are unwilling or not suitable for HRT. Clinical combination of HRT and diphosphate can both control menopausal symptoms and prevent fractures. Risedronate is a potent diphosphate that has the potential to relieve Paget’s disease, reduce bone turnover, increase bone density, and reduce fractures. The authors explored postmenopausal women