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胎儿和出生后骨发育传统上被认为是骨矿物质积累或骨量增加的过程。因此,新生儿和儿童早期骨发育的先期途径是增强峰值骨量的决定因子,以及这些因子与以后生活中骨质减少、骨质疏松和骨折等的关系。这提示新生儿期和儿童早期是骨矿物质积累的重要时期,并且峰值骨量可能与随后的骨健康相关。不过,仅根据骨量或骨密度变化描述胎儿和出生后骨发育意味着将骨看成类似于钙和磷的无定形堆积。当然,事实上,骨是复杂的三维立体结构。因此,创造刺激骨变得更坚固的条件是重要的。我们认为功能骨生理学能够用于解释胎儿和出生后骨发育及设计改善早产儿和新生儿骨发育的策略。
Fetal and postnatal bone development has traditionally been thought to be a process of bone mineral accumulation or bone mass gain. Therefore, the earliest pathways for early bone development in newborns and children are the determinants of increased peak bone mass, as well as the relationship of these factors with subsequent osteopenia, osteoporosis and fractures. This suggests that neonatal and early childhood are an important period of bone mineral accumulation and peak bone mass may be associated with subsequent bone health. However, describing the fetus and postnatal bone development solely on the basis of changes in bone mass or bone density means that the bone is seen as an amorphous accumulation similar to calcium and phosphorus. Of course, in fact, bone is a complex three-dimensional structure. Therefore, it is important to create conditions that stimulate the bone to become firmer. We believe that functional bone physiology can be used to explain fetal and postnatal bone development and to design strategies to improve bone development in preterm and newborn infants.