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目的:探讨炎琥宁肠溶微丸释放度的测定方法。方法:选用0.1 mol/L的盐酸溶液和pH 6.8的磷酸盐缓冲液为溶出介质,采用紫外分光光度法确定炎琥宁测定波长,制备标准曲线,考察吸收度与浓度的线性关系,通过精密度与回收率实验考察是否符合测定要求。结果:选择251 nm为炎琥宁的测定波长,炎琥宁在0.1 mol/L的盐酸溶液中10～40μg/mL、在pH 6.8的磷酸盐缓冲液中20～50μg/mL浓度范围内吸收度与浓度均呈良好的线性关系,精密度和回收率高。结论:紫外分光光度法测定炎琥宁肠溶微丸的释放度,方法简便、灵敏,符合测定要求。
Objective: To investigate the determination of the release of Yanhuaning enteric-coated pellets. Methods: The 0.1 mol / L hydrochloric acid solution and pH 6.8 phosphate buffer were used as dissolution medium. The determination wavelength of metronidazole was determined by ultraviolet spectrophotometry. The calibration curves were prepared. The linear relationship between the absorbance and the concentration was investigated. Experiment with the recovery rate to determine whether the test requirements. Results: 251 nm was selected as the determination wavelength of memantine, 10 ~ 40 μg / mL of mesylate in 0.1 mol / L hydrochloric acid and 20 ~ 50 μg / mL in pH 6.8 phosphate buffer And the concentration showed a good linear relationship, high precision and recovery. Conclusion: UV-spectrophotometry determination of the release of Yanhuaning enteric-coated pellets, the method is simple and sensitive, in line with the determination requirements.