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目的研究非诺贝特对高三酰甘油血症患者胰岛素敏感性的影响。方法 45例高甘油三脂血症患者每晚睡前口服微粒化非诺贝特200 mg,连续服用12周,于治疗前后对血脂情况和胰岛素抵抗情况进行测定。结果治疗后HDL-C显著升高,TG、TC、LDL-C、FFA显著降低,与治疗前比较差异有统计学意义(P<0.05);治疗后HOMA-IR、FINS、2 hINS均有所下降,与治疗前比较差异有统计学意义(P<0.05)。结论非诺贝特不但具有调节血脂的作用,还具有胰岛素增敏作用,是治疗高甘油三脂血症的可靠、有效的药物,值得临床借鉴和应用。
Objective To investigate the effect of fenofibrate on insulin sensitivity in patients with hypertriglyceridemia. Methods 45 patients with hypertriglyceridaemia received 200 mg micronized fenofibrate every night before going to bed. The patients were treated for 12 weeks continuously before and after treatment. The blood lipid and insulin resistance were measured before and after treatment. Results After treatment, the levels of HDL-C, TG, TC, LDL-C and FFA were significantly lower than those before treatment (P <0.05). After treatment, the levels of HOMA-IR, FINS, Decreased, compared with before treatment was statistically significant (P <0.05). Conclusion Fenofibrate not only has the effect of regulating blood lipids, but also has the effect of insulin sensitization. It is a reliable and effective drug for the treatment of hypertriglyceridemia, and is worthy of clinical reference and application.