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本实验应用离体兔心做功模型,研究了不同浓度的人参总皂甙(GS)对心肌缺血再灌注损伤的影响。通过心肌活检电镜下线粒休半定量法评价计分,结论如下:人参总皂甙作为高钾心脏停搏液的添加剂,在20~80mg/L的浓度范围内,具有抗心肌缺血再灌注损伤作用,其作用随浓度递增而增强;当其浓度。为160mg/L时,失去上述作用,反而有加重心肌缺血再灌注损伤的倾向。
In this study, rabbit heart function model was used to study the effects of different concentrations of ginsenoside (GS) on myocardial ischemia-reperfusion injury. Myocardial biopsy under electron microscopy, mitochondrial hallux quantitative evaluation of scoring, the conclusions are as follows: As a high potassium cardioplegia ginsenoside additive, 20 ~ 80mg / L concentration range, with anti-myocardial ischemia-reperfusion injury Role, its role with increasing concentration and enhanced; when its concentration. 160mg / L, the loss of the above effect, but tend to aggravate myocardial ischemia-reperfusion injury.