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硝酸甘油是一个很老的药物,由于疗效确切,所以它仍然是目前国内外缓解心绞痛的首选药物之一。但硝酸甘油片的稳定性等质量问题,却一直没有很好地得以解决。硝酸甘油含量不稳定的原因除由于硝酸甘油易挥发外,尚有药片之间硝酸甘油的互相迁移和包装材料对硝酸甘油的吸附。为此,国外曾在硝酸甘油药片中加入聚乙二醇、微晶纤维、聚乙烯吡咯烷酮等以稳定硝酸甘油,并减少它们的迁移作用,发现以聚乙烯吡咯烷酮为最好。我们的实验证明:用膜剂基质聚乙烯醇制成的硝酸甘油膜其稳定性也很好。
Nitroglycerin is a very old drug, because of the exact effect, so it is still one of the preferred drugs for relieving angina at home and abroad. However, the stability of nitroglycerin and other quality problems, but has not been well resolved. The reason for the unstable content of nitroglycerin is due to the volatility of nitroglycerin, the migration of nitroglycerin between the tablets and the adsorption of nitroglycerin by the packaging material. To this end, foreign countries have in the nitroglycerin tablets polyethylene glycol, microcrystalline fiber, polyvinylpyrrolidone and so on to stabilize the nitroglycerin and reduce their migration, found that polyvinylpyrrolidone is best. Our experiment shows that the stability of the nitroglycerin membrane made of polyvinyl alcohol is good.