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目的 了解H_1和H_2受体在肝硬变门静脉高压症大鼠和病人肝组织中的变化。方法 应用~3H-吡拉明和~3H-甲氰咪胍对四氯化碳诱导的10只大鼠肝硬变模型和8例乙型肝炎后肝硬变病人的肝组织进行光学放射自显影研究。结果 肝组织结构的H_1、H_2受体密度(每1000μm~2银粒计数)对照组/肝硬变大鼠分别为,H_1受体:肝细胞346.5±31.8/116.9±17.7,肝静脉276.9±17.6/27.1±4.6,肝动脉31.4±6.9/12.4±3.1,肝门静脉24.7±10.7/15.8±3.8;H_2受体:肝细胞288.9±21.2/168.0±23.7,肝动脉234.6±8.7/153.7±25.2,肝门静脉229.8±28.3/148.3±18.0,肝静脉261.3±35.8/141.0±18.3。对照组/肝硬变病人H_1受体:肝细胞68.7±8.7/63.1±5.5,肝动脉40.6±7.5/35.5±4.7,肝门静脉38.8±5.2/34.4±6.8,肝静脉35.6±8.2/34.7±5.0;H_2受体:肝细胞511.9±37.6/168.4±22.6,肝动脉175.4±26.1/55.6±7.1,肝门静脉166.4±17.7/52.0±5.4,肝静脉313.0±52.4/238.8±40.7。结论 大鼠以H_1受体占优势,人以H_2受体为主;肝硬变大鼠及病人肝组织结构上的H_1、H_2受体低于对照组。
Objective To investigate the changes of H 1 and H 2 receptors in liver tissues of rats and patients with cirrhosis and portal hypertension. Methods The optical autoradiographic study of 10 rats with cirrhosis induced by carbon tetrachloride and 8 cases of liver cirrhosis patients with cirrhosis was performed using ~ 3H-pyriprozin and ~ 3H-cimetidine. . Results The density of H 1 and H 2 receptors in the liver tissue (counts per 1000 μm ~ 2 of silver particles) in control group and cirrhotic rats were respectively: H 1 receptor: hepatocytes 346.5 ± 31.8 / 116.9 ± 17.7 and hepatic vein 276.9 ± 17.6 /27.1 ± 4.6, hepatic artery 31.4 ± 6.9 / 12.4 ± 3.1, hepatic portal vein 24.7 ± 10.7 / 15.8 ± 3.8; H 2 receptor: hepatocytes 288.9 ± 21.2 / 168.0 ± 23.7, hepatic artery 234.6 ± 8.7 / 153.7 ± 25.2, liver Portal vein 229.8 ± 28.3 / 148.3 ± 18.0, and hepatic vein 261.3 ± 35.8 / 141.0 ± 18.3. H 1 receptors in control group and cirrhotic patients were: hepatocytes 68.7 ± 8.7 / 63.1 ± 5.5, hepatic artery 40.6 ± 7.5 / 35.5 ± 4.7, hepatic portal vein 38.8 ± 5.2 / 34.4 ± 6.8 and hepatic vein 35.6 ± 8.2 / 34.7 ± 5.0 ; H 2 receptors: 511.9 ± 37.6 / 168.4 ± 22.6, hepatocytes 175.4 ± 26.1 / 55.6 ± 7.1, hepatic portal vein 166.4 ± 17.7 / 52.0 ± 5.4, and hepatic veins 313.0 ± 52.4 / 238.8 ± 40.7. Conclusions H 1 receptor predominates in rats and H 2 receptors predominate in humans. H 1 and H 2 receptors in liver tissues of cirrhotic rats and patients are lower than those in control group.