本文报道了二性霉素乙治疗中由于其副作用以及病人病情恶化而改用咪可那唑治疗的概况。1例50岁病人皮肤与皮下组织有大小不同的压痛结节,分布于右肩、左腰、上臂、右股及左唇上部,最大的结节直径达6厘米。体检:血红蛋白11.2克%,血球压积37%,白细胞19800/立方毫米,中性白细胞93%,尿素氮7毫克%,血清肌酐1毫克%, This article reports the general situation of amphotericin B in the treatment of miconazole because of its side effects and the worsening of the patient’s condition. One case of 50-year-old patient with subcutaneous tissue of different sizes and tender nodules, located in the right shoulder, left waist, upper arm, right femoral and upper left lip, the largest nodule diameter of 6 cm. Physical examination: hemoglobin 11.2 g%, hematocrit 37%, leukocytes 19800 / cubic mm, neutrophils 93%, urea nitrogen 7 mg%, serum creatinine 1 mg%