论文部分内容阅读
目的观察对比硝酸甘油、酚妥拉明对妊娠高血压危象的治疗作用,总结其临床用药经验和应用价值。方法选取我院2010年6月至2012年6月妊娠高血压危象的患者82例,按照数字表随机抽取的方法将其分成观察组与对照组,各有41例。观察组使用硝酸甘油加5%的葡萄糖溶液进行静脉滴注治疗;对照组使用酚妥拉明加5%的葡萄糖溶液进行静脉滴注治疗,观察对比两组治疗前后的血压、心率变化,治疗期间药物不良反应率及治疗后母儿结局。结果两组患者治疗后的舒张压、收缩压与治疗前相比,皆有明显下降(P<0.05),组间比较无显著性差异(P>0.05);两组药物不良反应发生率对比差异不显著(P>0.05)。结论硝酸甘油、酚妥拉明皆是治疗妊娠高血压危象的有效药物,均能明显降低血压,改善胎儿血液供应,其中的硝酸甘油治疗期间不会引起低血压或心率加快,安全性更高。
Objective To compare the therapeutic effect of nitroglycerin and phentolamine on crisis of pregnancy induced hypertension, and summarize the experience and value of clinical application. Methods Totally 82 patients with hypertensive crisis of pregnancy in our hospital from June 2010 to June 2012 were randomly divided into observation group and control group according to digital table, each with 41 cases. The observation group was treated with nitroglycerin plus 5% glucose solution for intravenous drip. The control group was treated with intravenous infusion of phentolamine plus 5% glucose solution. The changes of blood pressure and heart rate before and after treatment were observed and compared. Adverse drug reaction rate and maternal and child outcomes after treatment. Results After treatment, the diastolic blood pressure and systolic blood pressure were significantly decreased in both groups (P <0.05), but there was no significant difference between the two groups (P> 0.05). The incidence of adverse drug reactions in the two groups was significantly lower than that before treatment Not significant (P> 0.05). Conclusion Both nitroglycerin and phentolamine are effective drugs for the treatment of crisis of pregnancy-induced hypertension, and both can significantly lower blood pressure and improve blood supply to the fetus, in which nitroglycerin does not cause hypotension or heart rate during treatment, and has higher safety .