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目的分析对老年急性心肌梗死(AMI)患者进行血浆肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)检测的临床诊断价值及对治疗的临床价值。方法 80例老年AMI患者作为观察组,80例体检健康人员作为对照组。采集两组受检者的晨起空腹静脉血液标本进行血浆hs-CRP、TNF-α水平检测,观察不同时段观察组患者血浆hs-CRP、TNF-α水平与对照组的差异,以及观察组治疗后不同疗效患者的血浆hs-CRP、TNF-α水平差异。结果观察组患者入院时及入院后第1天、5天、10天血浆hs-CRP、TNF-α水平与对照组比较,差异具有统计学意义(P<0.05);治疗结束后观察组患者的血浆hs-CRP水平为(0.62±0.22)μg/ml、TNF-α水平为(21.02±8.58)pg/ml,与对照组的(0.58±0.19)μg/ml、(19.99±7.86)pg/ml比较差异无统计学意义(P>0.05)。观察组疗效越好的患者血浆hs-CRP、TNF-α水平下降幅度越大,差异有统计学意义(P<0.05)。结论血浆hs-CRP、TNF-α是炎性反应的特异性指标,对老年AMI患者早期诊断及治疗效果评估中具有参考价值。
Objective To analyze the clinical diagnostic value of plasma tumor necrosis factor-α (TNF-α) and high-sensitivity C-reactive protein (hs-CRP) in elderly patients with acute myocardial infarction (AMI) and its clinical value. Methods Eighty elderly patients with AMI were selected as the observation group and 80 healthy people as the control group. The fasting venous blood samples from two groups were collected to detect plasma hs-CRP and TNF-α levels, and the differences of plasma hs-CRP and TNF-α levels between the observation group and the control group were observed at different time points. After different effects of plasma hs-CRP, TNF-α levels were different. Results The plasma levels of hs-CRP and TNF-α in the observation group were significantly higher than those in the control group on admission and on the first, fifth and tenth days after admission (P <0.05). After the treatment, the levels of hs- The level of hs-CRP in plasma was (0.62 ± 0.22) μg / ml and the level of TNF-α was (21.02 ± 8.58) pg / ml, which was significantly higher than that of the control group (0.58 ± 0.19μg / ml, (19.99 ± 7.86) pg / ml The difference was not statistically significant (P> 0.05). The decrease of plasma hs-CRP and TNF-α level in the observation group with better curative effect was statistically significant (P <0.05). Conclusions Plasma hs-CRP and TNF-α are the specific indexes of inflammatory reaction, which have reference value in the early diagnosis and treatment of elderly patients with AMI.