恶性组织细胞病(MH)是一种少见的进展迅速的致死性疾病。它具有发热,消耗,肝、脾肿大,全血减少和淋巴结肿大等特征,但在就诊时可以无症状或症状不典型。单药化疗效果不满意,联合化疗特别是含有阿霉素在内者取得了好的效果。但绝大多数研究没有进行免疫组织化学检查以除外大细胞间变淋巴瘤或噬血细胞综合征。这些研究多数完全缓解率较高(50～90%),且随访时间短。作者对12例 MH 的临床、诊断及治疗作评价。病人和结果 1974～1988年作者收治75例组织细胞增生症患者。其中由严重病毒感染引起的噬血细胞 Malignant histiocytosis (MH) is a rare, fatal disease that progresses rapidly. It has the characteristics of fever, consumption, liver, splenomegaly, pancytopenia and lymph nodes, but can be asymptomatic or atypical when treated. Chemotherapy alone is not satisfied with the results, combined with chemotherapy, especially with doxorubicin, including those who achieved good results. However, the vast majority of studies did not carry out immunohistochemical examination to exclude large cell lymphoma or hemophagocytic syndrome. Most of these studies have a high complete remission rate (50-90%) and follow-up time is short. The authors evaluate the clinical, diagnosis and treatment of 12 cases of MH. Patients and Results The authors treated 75 patients with histiocytosis from 1974 to 1988. Among them are hemophagocytic cells caused by severe virus infection