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目的:探讨右肺动脉神经节丛(RPVGP)消融对胆碱能及儿茶酚胺诱发房颤的影响。方法:20只犬麻醉开胸后,暴露RPVGP,分别在消融RPVGP前后,经股静脉静滴乙酰胆碱(ACh)及儿茶酚胺。测量房颤诱发率及两类递质诱发房颤的阈浓度。结果:RPVGP消融前,静滴Ach和异丙基肾上腺素(IPA)及肾上腺素(EPI)(1～100μmol/l)均可诱发AF,诱发率100%。Ach、IPA和EPI的诱发阈浓度分别为2.6±0.3μmol/l,3.3±0.2μmol/l,5.6±0.2μmol/l。RPVGP消融后,Ach及儿茶酚胺的AF诱发率分别降至10%及35%,且三种递质的诱发阈浓度分别提高至2.6±0.3μmol/l、22.5±2.4μmol/l和26.±2.6μmol/(lP<0.05)。结论:消融RPVGP使乙酰胆碱和儿茶酚胺诱发房颤的阈浓度增高,并降低此二类介质的房颤诱发率。
Objective: To investigate the effect of ablation of right pulmonary artery ganglion plexus (RPVGP) on cholinergic and catecholamine-induced atrial fibrillation. Methods: Twenty rabbits were exposed to RPVGP after anesthesia and thoracotomy. Acetylcholine (ACh) and catecholamine were intravenously dripped via femoral vein before and after ablation of RPVGP. The incidence of atrial fibrillation and the threshold concentrations of two types of neurotransmitter-induced atrial fibrillation were measured. Results: Before RPVGP ablation, intravenous infusion of Ach and IPA and epinephrine (EPI) (1-100 μmol / l) induced AF with a rate of 100%. The induced threshold concentrations of Ach, IPA and EPI were 2.6 ± 0.3μmol / l, 3.3 ± 0.2μmol / l and 5.6 ± 0.2μmol / l, respectively. After RPVGP ablation, the induced rates of AF induced by Ach and catecholamines were reduced to 10% and 35%, respectively, and the induced threshold concentrations were increased to 2.6 ± 0.3μmol / l, 22.5 ± 2.4μmol / l and 26 ± 2.6 μmol / (lP <0.05). Conclusion: The ablation of RPVGP increases the threshold concentration of acetylcholine and catecholamine-induced atrial fibrillation and decreases the induction rates of atrial fibrillation in these two types of media.