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目的探讨绝经后妇女骨质疏松症采用利塞膦酸钠防治的有效性和药理作用。方法 100例绝经后妇女骨质疏松症患者随机分为治疗组和对照组,各50例。两组患者均口服1片/d钙尔奇D600,治疗组患者在此基础上于每日早餐前口服1片利塞膦酸钠治疗,两组患者均连续给药6个月。于治疗前后对两组患者的腰椎和髋部骨密度进行测量,并对比结果。结果治疗组患者治疗后的腰椎和髋部骨密度改善优于对照组,差异有统计学意义(P<0.05);治疗组总有效率为94%,对照组总有效率为66%;两组患者均未出现明显不良反应。结论绝经后妇女骨质疏松症采用利塞膦酸钠治疗可有效改善患者骨密度,安全性好,值得推广。
Objective To investigate the effectiveness and pharmacological effects of risedronate on prevention and treatment of osteoporosis in postmenopausal women. Methods 100 cases of postmenopausal women with osteoporosis were randomly divided into treatment group and control group, 50 cases each. Two groups of patients were oral administration of 1 / d Galci D600, the treatment group patients on the basis of this in the daily oral administration of a tablet of risedronate sodium treatment, both groups were given continuous administration of 6 months. Before and after treatment, the BMD of lumbar spine and hip in both groups were measured and compared. Results The BMD of the lumbar spine and hip after treatment in the treatment group was better than that in the control group (P <0.05). The total effective rate was 94% in the treatment group and 66% in the control group. The two groups No significant adverse reactions in patients. Conclusion Postmenopausal women osteoporosis with risedronate sodium treatment can effectively improve the patient’s bone mineral density, good safety, it is worth promoting.