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目的:探讨胰岛素联合六味地黄丸治疗老年早期糖尿病肾病患者的临床疗效。方法:收集我院收治的老年早期糖尿病肾病患者100例,随机分为对照组和实验组,每组各50例,对照组患者血糖情况给予胰岛素1次~2次/d,实验组患者在此基础上给予六味地黄丸1丸/次,2次/d,口服。连续4周。治疗结束后,对患者血清糖基化血红蛋白(Hb A1c)、同型半胱氨酸(HCY)、胱抑素C(Cys-C)水平的变化及临床疗效进行检测并比较。结果:与治疗前相比,两组患者的Hb A1c、HCY、Cys-C均下降(P<0.05);与对照组相比,实验组患者Hb A1c、HCY、Cys-C水平较低(P<0.05),实验组患者治疗总有效率较高(P<0.05)。结论:胰岛素联合六味地黄丸能够有效改善老年早期糖尿病肾病患者的糖稳态及肾功能,临床疗效较好。
Objective: To investigate the clinical efficacy of insulin combined with Liuweidihuangwan in the treatment of senile patients with early diabetic nephropathy. Methods: A total of 100 elderly patients with diabetic nephropathy who were admitted to our hospital were randomly divided into control group and experimental group, with 50 cases in each group. The patients in control group were given insulin once or twice a day for 2 weeks. The patients in experimental group On the basis of giving Liu Wei Di Huang Wan 1 pill / time, 2 times / d, orally. For 4 weeks. After treatment, the levels of serum glycosylated hemoglobin (Hb A1c), homocysteine (HCY) and cystatin C (Cys-C) in patients were measured and compared. Results: Hb A1c, HCY and Cys-C in both groups were significantly lower than those before treatment (P <0.05). Compared with the control group, the levels of Hb A1c, HCY and Cys-C in the experimental group were lower <0.05). The total effective rate of treatment group was higher (P <0.05). Conclusion: The combination of insulin and Liuweidihuangwan can effectively improve the glycogen homeostasis and renal function in elderly patients with early diabetic nephropathy.