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目的探讨原发性肝癌的治疗方法和预后因素。方法通过随访回顾性分析121例经股动脉穿刺行经肝动脉化疗栓塞术(Transcatheter arterial chemoembolization,TACE)治疗原发性肝癌患者的病例资料,依据影像学及生存时间判断疗效,并对影响预后的因素进行分析。结果 1年、2年、3年生存率分别为47.1%、11.6%、4.1%,中位生存期15.2个月。完全缓解(CR)2例,部分缓解(PR)33例,总有效率(CR+PR)28.9%。对患者生存期影响显著的因素包括临床分期、术前肝功能、肿瘤大体形态和TACE次数。结论影响原发性肝癌预后的影响因素有多种,TACE是治疗原发性肝癌的有效治疗手段,可提高生活质量,延长患者生存期。
Objective To investigate the treatment and prognostic factors of primary liver cancer. Methods The clinical data of 121 patients with primary hepatocellular carcinoma treated by transcatheter arterial chemoembolization (TACE) via femoral artery puncture were retrospectively analyzed. The therapeutic effect was evaluated according to the imaging and survival time, and the prognostic factors Analyze. Results The 1-year, 2-year and 3-year survival rates were 47.1%, 11.6% and 4.1%, respectively. The median survival time was 15.2 months. Two patients had complete remission (CR), 33 had partial remission (PR), and the total effective rate (CR + PR) was 28.9%. Factors that significantly affected patient survival included clinical stage, preoperative liver function, gross tumor morphology and TACE frequency. Conclusion There are many influencing factors for the prognosis of primary liver cancer. TACE is an effective treatment for primary liver cancer, which can improve the quality of life and prolong the survival of patients.