论文部分内容阅读
目的:探讨多次肝动脉化疗栓塞术(TACE)对肝癌患者肝纤维化进程的影响。方法:选择24倒经3次以上TACE治疗的肝癌患者,测定他们每次TACE治疗前后透明质酸(HA)、人Ⅲ型前肢原(hPC Ⅲ)和Ⅳ型胶原(ⅣC)的血清学水平,并进行比较研究。结果:TACE治疗前后对比,3次肝纤维化指标均有不同程度的升高,以第3次TACE术后升高最明显(P<0.01),3项肝纤维化指标中,以ⅣC变化最显著,第1次TACE术后即有统计学意义(P<0.05)。结论:TACE治疗加重了肝纤维化进展,值得注意。
Objective: To investigate the effect of multiple transcatheter arterial chemoembolization (TACE) on hepatic fibrosis in patients with liver cancer. Methods: The serum levels of hyaluronic acid (HA), human forelimb (hPC Ⅲ) and type Ⅳ collagen (ⅣC) before and after TACE treatment were measured in 24 HCC patients who underwent TACE over 3 times. And make a comparative study. Results: Before and after TACE treatment, all the indexes of liver fibrosis were increased to some extent, and the most obvious increase was found after the third TACE (P <0.01). Among the three indexes of liver fibrosis, the change of Ⅳ C was the most Significantly, after the first TACE was statistically significant (P <0.05). Conclusion: TACE treatment aggravates the progress of liver fibrosis, it is worth noting.