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目的探讨降钙素原(PCT)、C反应蛋白(CRP)及白细胞介素-6(IL-6)在慢性乙型肝炎诊断和治疗中的意义。方法收集2013年5月至2014年3月接受治疗的慢性乙型肝炎患者60例,作为观察组;选取同期60例健康查体者作为对照组。检测其血清CRP、PCT及IL-6水平,分析这些指标在慢性乙型肝炎诊断和治疗中的意义。结果观察组CRP、PCT、IL-6水平分别为(10.7±6.8)mg/L、(11.2±6.1)μg/L、(253.2±45.1)ng/L,明显高于对照组的(3.3±1.0)mg/L、(1.2±0.5)μg/L、(64.5±10.1)ng/L,两组比较差异具有统计学意义(P<0.05)。经ROC曲线分析,CRP敏感性为56.9%,特异性为70.6%;IL-6敏感性为92.3%,特异性为95.5%;PCT敏感性为67.5%,特异性为85.0%。结论 PCT、CRP及IL-6联合检测对慢性乙型肝炎的诊断及治疗具有非常重要的临床价值。
Objective To investigate the significance of procalcitonin (PCT), C-reactive protein (CRP) and interleukin-6 (IL-6) in the diagnosis and treatment of chronic hepatitis B. Methods Sixty patients with chronic hepatitis B who were treated from May 2013 to March 2014 were selected as the observation group. Sixty healthy subjects from the same period were selected as the control group. The levels of serum CRP, PCT and IL-6 were detected and the significance of these indexes in the diagnosis and treatment of chronic hepatitis B were analyzed. Results The levels of CRP, PCT and IL-6 in the observation group were (10.7 ± 6.8) mg / L and (11.2 ± 6.1) μg / L and (253.2 ± 45.1) ng / L, (1.2 ± 0.5) μg / L and (64.5 ± 10.1) ng / L, respectively. There was significant difference between the two groups (P <0.05). The ROC curve analysis showed that the sensitivity and specificity of CRP were 56.9% and 70.6% respectively. The sensitivity and specificity of IL-6 were 92.3% and 95.5% respectively. The sensitivity and specificity of PCT were 67.5% and 85.0% respectively. Conclusion The combined detection of PCT, CRP and IL-6 has a very important clinical value in the diagnosis and treatment of chronic hepatitis B.