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建立了液体顶空气相色谱法测定蒿甲醚中有机溶剂残留量。采用DB-1大口径毛细管柱,以对照品作外标进行定量。甲醇、乙醇及二氯甲烷的线性范围分别为30.2~635.2μg·mL-1(r=0.9991),6.4~64.5μg·mL-1(r=0.9991)和5.5~68.7μg·mL-1(r=0.9990);回收率分别为99.9%,103.8%和99.3%;检测限分别为0.02μg·g-1,0.04μg·g-1和0.01μg·g-1。本方法简单、准确、灵敏度及重现性好。
A liquid headspace gas chromatography was developed for the determination of organic solvent residues in artemether. Using DB-1 large diameter capillary column, with reference standard for external standard quantitative. The linear range of methanol, ethanol and dichloromethane were 30.2-635.2μg · mL-1 (r = 0.9991), 6.4-64.5μg · mL-1 (r = 0.9991) and 5.5-68.7μg · mL-1 = 0.9990). The recoveries were 99.9%, 103.8% and 99.3%, respectively. The detection limits were 0.02μg · g-1, 0.04μg · g-1 and 0.01μg · g-1, respectively. The method is simple, accurate, good sensitivity and reproducibility.