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探讨鸟氨酸α酮戊二酸对负荷肝细胞瘤Morris7777大鼠的作用。大鼠分别接受等氮、热卡的含鸟氨酸α酮戊二酸或甘氨酸的饲料。鸟氨酸α酮戊二酸已用于其它一些分解代谢状态（如创伤、败血症）。肿瘤植入自然生长3周后达11g／（100g体重），此时可以引起进行性的厌食、负氮平衡以及机体和组织的消耗。与甘氨酸比较，鸟氨酸α酮戊二酸既没有影响肿瘤的生长也没有改变肿瘤引起的宿主分解代谢变化。认为本研究以及当肿瘤占宿主体重4％～30％的报告中，强化营养支持效果欠佳的原因是由于肿瘤夺取了宿主的氨基酸。本实验证明肿瘤植入3周后，肿瘤自身的蛋白积累和对氨基酸氧化分解占宿主每日摄入蛋白量的～70％。由于临床工作中肿瘤总是在较小时被诊断并行初次治疗的。本实验进一步研究了手术切除肿瘤以限制疾病阶段后强化营养的作用。大鼠术前3天和术后3天或6天分别接受鸟氨酸α酮戊二酸或甘氨酸的饲料。鸟氨酸α酮戊二酸强化营养的大鼠其氮平衡、肌肉谷氨酰胺和支链氨基酸浓度、小肠蛋白积累高于甘氨酸强化营养的大鼠（P＜0．05）。本实验证明不切除肿瘤仅行营养支持其效果欠佳，而且为进一步实验研究建立了恰当的动物模型。
To investigate the effect of ornithine α-ketoglutarate on the load of hepatoma Morris7777 rats. The rats received isonitrogen and caloric diets containing ornithine alpha ketoglutarate or glycine, respectively. Ornithine alpha ketoglutarate has been used in other catabolic states (such as trauma, sepsis). Tumor implants reach 11g/(100g body weight) after 3 weeks of natural growth, which can cause progressive anorexia, negative nitrogen balance, and body and tissue depletion. Compared to glycine, ornithine alpha oxoglutarate neither affects tumor growth nor changes tumor-induced changes in host catabolism. In this report and in the report that tumors accounted for 4% to 30% of the host body weight, the reason for the poor nutrition support effect was due to tumors that seized host amino acids. This experiment demonstrated that 3 weeks after tumor implantation, the tumor’s own protein accumulation and oxidative decomposition of amino acids account for ~70% of the daily intake of the host protein. Due to the fact that the tumors are always smaller at the time of clinical work, they are diagnosed in parallel for the initial treatment. This experiment further studied the role of surgical resection of the tumor to limit the strengthening of nutrition after the disease stage. The animals received ornithine ketoglutarate or glycine feed 3 days before surgery and 3 or 6 days after surgery. Rats with ornithine α-ketoglutarate fortified nutrient had higher nitrogen balance, higher muscle glutamine and branched-chain amino acid concentration, and smaller intestinal protein accumulation than glycine-enriched rats (P<0.05). This experiment proved that the effect of not only removing the tumor but only supporting the nutrient was not good, and an appropriate animal model was established for further experimental studies.