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目的:研究低出生体重儿乙肝疫苗免疫持久性与安全性。方法:选择86例低出生体重儿作为研究组,另选取86例正常出生体重儿作为对照组,分别对两组接种全程酵母乙肝疫苗后的抗-HBs阳性率、抗体平均滴度进行检测,并观察不良反应的发生情况。结果:研究组与对照组接种全程乙肝疫苗后3年内的抗-HBs的有效阳性率分别是74%和72.1%(P>0.05),抗体平均滴度分别是214.2 mIU/mL与210.8 mIU/mL(P>0.05);6年内的抗-HBs的有效阳性率分别是82.6%和81.4%(P>0.05),抗体平均滴度分别是178.6 mIU/mL与170.4 mIU/mL(P>0.05)。研究组与对照组接种第1针、第2针乙肝疫苗后均未发现发热、体温波动与败血症等不良反应。结论:免疫后数年内,低出生体质量对乙肝疫苗抗体的持久性没有影响,也不影响乙肝疫苗抗体的安全性。
Objective: To study the immune persistence and safety of low birth weight infant hepatitis B vaccine. Methods: Totally 86 low birth weight infants were selected as research group and 86 normal birth weight infants were selected as control group. The positive rate of anti-HBs and the average antibody titer of the two groups were detected respectively Observe the occurrence of adverse reactions. Results: The positive rates of anti-HBs in study group and control group within 3 years after inoculation of whole-dose hepatitis B vaccine were 74% and 72.1% respectively (P> 0.05). The average antibody titer was 214.2 mIU / mL and 210.8 mIU / mL (P> 0.05). The positive rates of anti-HBs in six years were 82.6% and 81.4% respectively (P> 0.05). The average antibody titer was 178.6 mIU / mL and 170.4 mIU / mL, respectively. The study group and the control group were vaccinated the first and second needle hepatitis B vaccine were found no fever, body temperature fluctuations and sepsis and other adverse reactions. Conclusion: In a few years after immunization, the low birth weight has no effect on the persistence of hepatitis B vaccine antibody, and does not affect the safety of hepatitis B vaccine antibody.