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本文在大鼠内毒素休克模型上，观察了肝线粒体结构和功能与Ｃａ￣（２＋），Ｍｇ￣（２＋）含量变化的关系。结果发现：休克动物肝组织和线粒体的Ｃａ￣（２＋）浓度升高，Ｍｇ￣（２＋）浓度下降与正常对照组相比有非常显著性差异；用图像分析仪定量分析显示线粒体结构明显受损，线粒体标志酶之一──琥珀酸脱氢酶（ＳＤＨ）活性明显下降，本文认为组织和线粒体内Ｍｇ￣（２＋）／Ｃａ￣（２＋）比值下降是休克细胞不可逆损伤重要因素之一。
In this paper, the rat model of endotoxic shock was observed, the relationship between mitochondrial structure and function of liver and Ca ~ (2 +), Mg ~ (2+) content changes. The results showed that the concentration of Ca ~ (2+) in liver tissue and mitochondria of shock animals increased and the concentration of Mg ~ (2+) decreased significantly compared with that of the normal control group. Quantitative analysis with image analyzer showed that the mitochondrial structure was obviously damaged , One of the mitochondrial marker enzymes, succinate dehydrogenase (SDH) activity was significantly decreased. It is considered that the decrease of the ratio of Mg 2+ / Ca 2+ in tissues and mitochondria is one of the important factors of irreversible injury of shock cells.