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转化生长因子α(TGFα)是一种含有50个氨基酸的单链多肽。在培养的肝细胞中,它受有丝分裂原刺激后表达,并诱导肝细胞自身DNA的合成。作者分析了暴发型肝炎(FH)患者血清TGFα水平,并与急性非暴发型肝炎(AH)患者进行了比较,旨在阐明两种病理状态下坏死后的肝脏再生。同时,作者还研究了血清TGFα水平与血清肝细胞生长因子(HGF)水平的关系,以及用胰高血糖素-胰岛素疗法(G-Ⅰ疗法)后两者的变化。
Transforming growth factor alpha (TGFα) is a single-chain polypeptide of 50 amino acids. In cultured hepatocytes, it is expressed upon stimulation by mitogen and induces the synthesis of hepatocytes’ own DNA. The authors analyzed serum TGFα levels in patients with fulminant hepatitis (FH) and compared them with patients with acute non-fulminant hepatitis (AH) to elucidate liver regeneration following necrosis in both pathologies. In the meantime, the authors also examined the relationship between serum TGFα levels and serum hepatocyte growth factor (HGF) levels, as well as changes in both after glucagon-insulin therapy (G-Ⅰ therapy).