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人类第9号染色体在人群中表现出高频率的结构性重排(如臂间倒位发生率高达1%),为了探讨其发生机理,我们通过姊妹染色单体交换(SCE)分析对此进行了研究,同时探讨9号染色体上 SCE 的频率和分布规律。我们参考 Bobrow 等的 Giemsa-11染色方法和 Alves 等的碱性溶液直按 SCD 法,摸索建立了同时显示 G—11染色和姊妹染色单体差别染色的新方法,对10名正常人、五名 inv(9)(P11,q13)携带者、二名 dup(9)(q1200→q2100)携带者、一名9qh+携带者进行了 SCE 分析。
Human chromosome 9 showed a high frequency of structural rearrangements in human populations (eg up to 1% in-arm inversion). To explore its mechanism of action, we performed this by sister chromatid exchange (SCE) analysis The study also explored the frequency and distribution of SCE on chromosome 9. We refer to Bobrow et al Giemsa-11 staining method and Alves and other alkaline solution straight SCD method to explore the establishment of a simultaneous display of G-11 staining and sister chromatid staining of new methods, 10 normal people, five Inv (9) (P11, q13) carriers, two dup (9) (q1200 → q2100) carriers, and one 9qh + carrier performed SCE analysis.