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目的:通过检测并分析胃癌患者血清Periostin、E-cadherine水平与胃癌临床病理参数的关系以评价两者对胃癌的临床应用价值。方法:应用固相夹心酶联免疫吸附实验(Elisa)检测54例胃良性疾病患者对照组和128例胃癌患者(胃癌组)血清Periostin、E-cadherine水平。结果:胃癌组血清Periostin[(409.429±154.851)pg/ml]、E-cadherine[(38.834±11.676)ng/ml]水平均显著高于对照组,差异有显著统计学意义(P<0.05)。胃癌根除组,有淋巴结转移组血清E-cadherine水平显著高于无淋巴结转移组,差异有统计学意义(P<0.05);血清Periostin水平随淋巴结转移个数的增多而升高,多重比较不同淋巴结转移个数分组差异有统计学意义(P<0.05);血清Periostin、E-cadherine水平随着胃癌浸润程度加深而升高,多重比较差异有统计学意义(P<0.05)。胃癌组,有远处器官转移组患者血清Periostin水平[(505.617±163.950)pg/ml]、E-cadherine[(48.705±8.067)ng/ml]均明显高于无远处转移组,差别有显著统计学意义(P<0.05)。胃癌组血清Periostin水平和血清E-cadherine水平呈低度正相关性。结论:血清Periostin、E-cadherine水平与胃癌的临床病理参数密切关系,对评价胃癌进展程度及预后有一定临床意义。
OBJECTIVE: To evaluate the clinical value of Periostin and E-cadherine in gastric cancer by detecting and analyzing the relationship between Periostin and E-cadherine and the clinicopathological parameters of gastric cancer. Methods: Serum Periostin and E-cadherine levels were measured in 54 patients with gastric benign disease and 128 patients with gastric cancer (gastric cancer) by solid-phase sandwich enzyme-linked immunosorbent assay (Elisa). Results: The levels of Periostin [(409.429 ± 154.851) pg / ml] and E-cadherine [(38.834 ± 11.676) ng / ml] in gastric cancer group were significantly higher than those in the control group, with significant difference (P <0.05). The levels of serum E-cadherine in patients with gastric cancer eradication and lymph node metastasis were significantly higher than those without lymph node metastasis (P <0.05). Periostin levels increased with the number of lymph node metastasis, and multiple comparisons of different lymph nodes (P <0.05). The levels of Periostin and E-cadherin in serum increased with the deepening of gastric cancer infiltration. There was significant difference between multiple comparisons (P <0.05). Serum Periostin levels in patients with gastric cancer and distant organ metastasis [(505.617 ± 163.950) pg / ml] and E-cadherine [(48.705 ± 8.067) ng / ml] were significantly higher than those without distant metastasis Statistical significance (P <0.05). There was a low positive correlation between serum Periostin level and serum E-cadherine level in gastric cancer group. Conclusion: The serum Periostin and E-cadherine levels are closely related to the clinicopathological parameters of gastric cancer, which is of clinical significance in evaluating the progression and prognosis of gastric cancer.