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目的观察白三烯受体拮抗剂(孟鲁司特)治疗和预防呼吸道合胞病毒(RSV)毛细支气管炎及感染后反复喘息的发生。方法选择2008年11月～2010年02月我院收治的RSV毛细支气管的住院患儿104例,随机分为治疗组(52例)和对照组(52例),在相同的综合治疗基础上,对照组常规使用激素和用布地奈德、异丙托溴铵、沙丁胺醇悬液雾化吸入,治疗组同时予孟鲁司特4mgpoqn,连用4周,观察急性期喘憋、呼吸困难、咳嗽、肺部喘鸣音消失时间,平均治疗天数及随访1月内喘息再发情况。结果两组比较差异均有统计学差异。结论应用白三烯受体拮抗剂(孟鲁司特)治疗RSV毛细支气管炎,可以明显缩短急性期病程,减少日后反复发作的喘息。
Objective To observe the effects of leukotriene receptor antagonist (montelukast) on the treatment and prevention of respiratory syncytial virus (RSV) bronchiolitis and repeated wheezing after infection. Methods From November 2008 to February 2010, 104 children admitted to our hospital with RSV bronchioles were randomly divided into treatment group (52 cases) and control group (52 cases). On the basis of the same comprehensive treatment, In the control group, hormones and budesonide, ipratropium bromide and salbutamol suspension were used for atomization inhalation. The patients in the treatment group were treated with montelukast 4 mg poqn for 4 weeks. The acute phase of wheezing, dyspnea, cough and lung Department of wheezing disappeared time, the average number of days of treatment and follow-up within 1 month wheezing recurrence. Results There were significant differences between the two groups. Conclusions Treatment of RSV bronchiolitis with leukotriene receptor antagonist (montelukast) can significantly shorten the course of acute phase and reduce recurrent wheezing in the future.