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目的观察坎地沙坦辅治合并冠心病的原发性高血压的临床效果。方法选取合并冠心病的原发性高血压患者80例作为研究对象,并按治疗用药的不同将其均分为观察组与对照组各40例。对照组予以单一坎地沙坦治疗,观察组在对照组的基础上予以其他抗高血压药物(氢氯噻嗪与硝苯地平缓释片)治疗,观察2组患者的临床疗效以及治疗前后血压、心率变化情况。结果观察组治疗总有效率为97.50%高于对照组的77.50%,差异有统计学意义(P<0.05)。治疗前2组收缩压、舒张压、心率比较差异无统计学意义(P>0.05);与对照组比较,治疗后观察组的心率上升、舒张压、收缩压下降,组间比较差异均有统计学意义(P<0.05)。结论坎地沙坦辅治合并冠心病的原发性高血压的效果优于单一使用坎地沙坦,且安全性能高,疗效快,值得临床推广应用。
Objective To observe the clinical effect of candesartan in the treatment of essential hypertension complicated with coronary heart disease. Methods Eighty patients with essential hypertension with coronary heart disease were selected as study subjects and divided into observation group and control group according to the different therapeutic drugs. The control group was treated with candesartan alone. The observation group was treated with other antihypertensives (hydrochlorothiazide and nifedipine sustained-release tablets) on the basis of the control group. The clinical effects and changes of blood pressure and heart rate before and after treatment were observed Happening. Results The total effective rate in the observation group was 97.50%, which was significantly higher than that in the control group (77.50%, P <0.05). There were no significant differences in systolic blood pressure, diastolic blood pressure and heart rate between the two groups before treatment (P> 0.05). Compared with the control group, heart rate, diastolic blood pressure and systolic blood pressure of the observation group decreased after treatment Significance (P <0.05). Conclusion Candesartan adjuvant combined with coronary heart disease in patients with essential hypertension better than single use of candesartan, and high safety performance, rapid response, it is worthy of clinical application.