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[目的]探讨微量泵皮下自控镇痛对晚期癌痛患者疼痛控制及生活质量的影响。[方法]将40例采用微量泵皮下自控镇痛(吗啡+利多卡因+氟哌利多)的晚期癌痛患者设为观察组,40例采用传统镇痛的晚期癌痛患者设为对照组,比较两组治疗后疼痛、镇静、生活质量以及不良反应的情况。[结果]观察组治疗第1d、第5d、第10d的疼痛评分均低于对照组,镇静程度好于对照组,差异均有统计学意义(P<0.05)。观察组48h的吗啡用量少于对照组,恶心、呕吐、皮肤瘙痒、呼吸抑制等不良反应的发生率低于对照组,差异有统计学意义(P<0.05)。观察组治疗后的生活质量问卷功能量表、症状量表以及总体生活质量表各方面的评分均好于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。[结论]微量泵皮下自控镇痛能明显减轻晚期癌痛患者的疼痛程度,提高镇静水平,改善生活质量,且不良反应少。
[Objective] To investigate the effect of subcutaneous subcutaneous controlled analgesia on pain control and quality of life in patients with advanced cancer pain. [Methods] Forty patients with advanced cancer pain controlled by subcutaneous subcutaneous analgesia (morphine + lidocaine + droperidol) were enrolled as the observation group. Forty patients with advanced cancer pain treated by traditional analgesia were selected as the control group, After treatment, pain, sedation, quality of life and adverse reactions were compared between the two groups. [Result] The scores of pain in the observation group on the 1st, 5th and 10th days were lower than those in the control group, and the sedation level was better than that in the control group (P <0.05). The observation group 48h morphine less than the control group, nausea, vomiting, skin itching, respiratory depression and other adverse reactions were lower than the control group, the difference was statistically significant (P <0.05). The score of functional questionnaire, symptom scale and overall quality of life questionnaire in the observation group after treatment were better than those in the control group, with significant difference (P <0.05). The incidence of adverse reactions in the observation group was lower than that in the control group, the difference was statistically significant (P <0.05). [Conclusion] Micro-pump subcutaneous controlled analgesia can significantly reduce the degree of pain in patients with advanced cancer pain, improve the level of sedation, improve the quality of life, and less adverse reactions.