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目的:探讨GnRH、SS及其受体在实验性急性末端回肠炎中的表达的变化及其意义。方法:选用健康成年雄性杂种犬40只,随机分成8组,每组5只,将后四组分别给予手枪弹颅脑火器伤造模,观察其GnRH、SS及其受体的变化。结果:术后各组实验犬血浆中GnRH、SS浓度的变化,在0.5h时各组实验犬血浆中GnRH、SS浓度明显下降,以后随时间延长GnRH、SS浓度呈现递增趋势;术后末端回肠组织GnRH受体、SS受体的表达变化,GnRHR、SSTR表达亦呈现先降低后增多的趋势,且GnRH、SS受体与对应GnRH、SS浓度呈现较好的一致性。结论:急性末端回肠炎血浆中GnRH、SS浓度升高及其受体的表达增多,GnRH、SS及其受体参与了急性末端回肠炎的调控。
Objective: To investigate the changes of GnRH, SS and their receptors in experimental acute terminal ileitis and its significance. Methods: Forty healthy adult male dogs were randomly divided into 8 groups (n = 5 each). The latter four groups were given gunshot wounds respectively to make models of craniocerebral gunshot wounds. The changes of GnRH, SS and their receptors were observed. Results: The changes of GnRH and SS in the plasma of experimental dogs in each group after operation showed that the concentration of GnRH and SS decreased significantly in each group of dogs at 0.5h, and then increased with the increase of GnRH concentration. The concentration of SS in the terminal ileum The expression of GnRH receptor and SS receptor, GnRHR and SSTR also decreased first and then increased, and the GnRH and SS receptors showed good consistency with the corresponding GnRH and SS concentrations. Conclusion: GnRH and SS in plasma and the expression of GnRH, SS are increased in acute terminal ileitis. GnRH, SS and their receptors are involved in the regulation of acute terminal ileitis.