目的探讨内源性雌、孕激素水平及其受体与宫颈癌发生的关系。方法采用病例对照研究方法,对141例宫颈癌患者、137例子宫肌瘤患者和129名健康妇女,用酶链免疫吸咐试验(ELISA)测定血清中雌二醇(E2)与孕酮(P)的含量,按照sABC免疫组化操作步骤进行宫颈组织中雌激素受体(ER)和孕激素受体(PR)的检测。结果宫颈癌组E2和P含量中位数分别为41．90 ng/ml和0．80 ng/ml,均明显高于两对照组,无论绝经与否,E2与宫颈癌的关联性均有统计学意义,并呈剂量反应关系,其归因危险度百分比(ARP)达89％以上。而以卵泡期正常参考值的下限浓度(2 pg/ml)为界进行定性分析,P与宫颈癌之间在绝经前后均无相关关系。宫颈癌组ER和PR的阳性率均低于子宫肌瘤组,但差异无统计学意义。结论内源性雌、孕激素的升高与宫颈癌的发生均有明显相关关系,特别是E2升高宫颈癌患病的风险更大,且不受绝经因素的影响,ER、PR对宫颈癌的发生可能具有一定的保护意义。 Objective To investigate the relationship between the levels of endogenous estrogen and progesterone and their receptors and the occurrence of cervical cancer. Methods A case-control study was conducted in 141 cases of cervical cancer, 137 cases of uterine fibroids and 129 healthy women. Serum estradiol (E2) and progesterone (P) were measured by enzyme-linked immunosorbent assay (ELISA) ), The estrogen receptor (ER) and progesterone receptor (PR) were detected in cervical tissue according to sABC immunohistochemical procedure. Results The median E2 and P levels in cervical cancer patients were 41.90 ng / ml and 0.80 ng / ml, respectively, which were significantly higher than those in the two control groups. The correlation between E2 and cervical cancer was statistically significant Significance, and dose-response relationship, the percentage of attributable risk (ARP) of more than 89%. However, the lower limit of normal reference follicular phase concentration (2 pg / ml) as a qualitative analysis of the community, P and cervical cancer before and after menopause were not related. The positive rates of ER and PR in cervical cancer group were lower than those in uterine fibroid group, but the difference was not statistically significant. Conclusion The increase of endogenous estrogen and progesterone has a significant correlation with the occurrence of cervical cancer. Especially, the risk of cervical cancer is higher with the increase of E2, and is not influenced by the menopausal factors. The effect of ER and PR on cervical cancer The occurrence may have some protective significance.