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目的分析中国汉族与蒙古族维生素D受体(VDR)基因多态性分布。方法应用PCR-RFLP技术,分别对我国179名汉族和112名蒙古族健康绝经后妇女的VDR基因型进行分型,并计算其基因频率分布。结果汉族和蒙古族绝经后妇女bb基因型频率分别为90·5%和50%,BB基因型频率分别为0%和4·46%,汉族与蒙古族之间VDR基因型频率分布差异非常显著(P<0·001)。结论我国汉族与蒙古族之间VDR基因型多态性具有种族差异性,这种种族差异性与骨质疏松的相关性有待于进一步研究。
Objective To analyze the distribution of vitamin D receptor (VDR) gene polymorphism in Han and Mongolians in China. Methods VDR genotypes of 179 Han and 112 Mongolian healthy postmenopausal women in China were genotyped by PCR-RFLP, and their gene frequency distribution was calculated. Results The frequencies of bb genotypes in Han and Mongolian postmenopausal women were 90.5% and 50%, respectively. The frequencies of BB genotypes were 0% and 4.46% respectively. The frequencies of VDR genotypes between Han and Mongolian were significantly different (P <0 · 001). Conclusion There is a racial difference in the VDR genotype polymorphism between Han and Mongolian ethnic groups in our country. The relationship between ethnic differences and osteoporosis remains to be further studied.