结直肠癌是人类最常见的恶性肿瘤之一,死亡率较高。在常规影像学发现肿瘤转移之前检测到外周血中隐匿存在的肿瘤细胞对预测肿瘤复发、转移、指导临床治疗等方面具有重要意义。端粒酶与细胞恶变、肿瘤的发生发展密切相关,而端粒酶催化亚基(hTERT)可能在端粒酶活性调节中起重要作 Colorectal cancer is one of the most common malignant tumors in humans and has a high mortality rate. Detecting the presence of secreted tumor cells in peripheral blood prior to detection of tumor metastasis by conventional imaging has important implications for predicting tumor recurrence, metastasis, and guiding clinical treatment. Telomerase is closely related to the malignant transformation of cells, the development of tumors, and the telomerase catalytic subunit (hTERT) may play an important role in the regulation of telomerase activity.