植物利用多个层次的抗病反应抵抗病原菌的入侵,包括表面受体激活的抗性(PTI)和胞内免疫受体激活的抗性(ETI)。内吞作用可将表面受体运输到胞内进行降解和循环利用,在PTI反应中发挥重要作用。研究表明网格蛋白介导的内吞作用是植物主要的内吞方式,然而植物如何调控内吞作用以及内吞如何参与先天免疫反应并不清楚。近期,中国科学院遗传与发育生物学研究所唐定中课题组利用拟南芥与白粉菌互作的研究体系,通过生化、遗传学和细胞学手段,克隆了拟南芥E- Plants use multiple levels of disease resistance to resist pathogen invasion, including surface receptor-activated resistance (PTI) and intracellular immune receptor-activated resistance (ETI). Endocytosis transports surface receptors into cells for degradation and recycling, playing an important role in PTI responses. Studies have shown that clathrin-mediated endocytosis is the major endocytosis of plants, but how plants regulate endocytosis and how endocytosis participates in the innate immune response is unclear. Recently, the Chinese Academy of Sciences Institute of Genetics and Developmental Biology Tang Dingzhong research group using Arabidopsis and powdery mildew interaction research system, through biochemical, genetic and cytological methods, cloned the Arabidopsis E-