局灶节段性肾小球硬化(FSGS)由多种病因引起,临床主要以大量蛋白尿及肾病综合征为主要表现,病理表现为肾小球局灶节段性硬化。患者主要表现为蛋白尿,并逐步进展为慢性肾功能不全。FSGS早期已存在足突广泛融合、凋亡、脱落及损伤,表明足细胞是其发生、发展的主要目标细胞。该文将近年来关于足细胞与FSGS的研究进展予以综述。 Focal segmental glomerulosclerosis (FSGS) is caused by a variety of causes, the main clinical manifestations of massive proteinuria and nephrotic syndrome, pathological manifestations of focal segmental sclerosis of the glomerulus. Patients mainly proteinuria, and gradually progress to chronic renal insufficiency. Foot FSGS already exists extensive fusion, apoptosis, shedding and injury in early stage, indicating that podocyte is the main target cell of its occurrence and development. In this paper, the research progress on podocyte and FSGS in recent years are reviewed.