Aim:To explore the anti-inflammatory effects of amurensin H on asthma-like reac-tion induced by allergen in sensitized mice.Methods:BALB/c mice were sensi-tized by ovalbumin(OVA,ip)on d 0 and d 14 and challenged with 1% OVA on d 18to 22.Mice developed airway eosinophilia,mucus hypersecretion,and elevationin cytokine levels.Mice were administered amurensin H orally at the doses of 49,70,or 100 mg/kg once every day from d 15 to the last day.Bronchoalveolar lavagefluid(BALF)were collected at 24 h and 48 h after the last OVA challenge.Levelsof tumor necrosis factor-α(TNF-α),interleukin 4(IL-4),interleukin 5(IL-5),andinterleukin 13(IL-13)in BALF were measured using ELISA method.Differentialcell counts of macrophages,lymphocytes,neutrophils and eosinophils were per-formed in 200 cells per slide(one slide per animal).Lung tissue sections of 6-μmthickness were stained with Mayer’s hematoxylin and eosin for assessment of cellinfiltration,mucus production,and tissue damage.Results:Oral administrationof amurensin H significantly inhibited OVA-induced increases in total cell counts,eosinophil counts,and TNF-α,IL-4,IL-5 and IL-13 levels in BALF.In addition,amuresin H dramatically decreased OVA-induced lung tissue damage and mucusproduction.Conclusion:Amurensin H may have therapeutic potential for thetreatment of allergic airway inflammation. Aim: To explore the anti-inflammatory effects of amurensin H on asthma-like reac-tion induced by allergen in sensitized mice. Methods: BALB / c mice were sensi-tized by ovalbumin (OVA, ip) on d 0 and d 14 and challenged with 1% OVA on d 18to 22.Mice developed airway eosinophilia, mucus hypersecretion, and elevationin cytokine levels. Mice were administered amurensin H orally at the doses of 49,70, or 100 mg / kg once every day from d 15 to the last day. Bronchoalveolar lavage fluid (BALF) were collected at 24 h and 48 h after the last OVA challenge. Levels of tumor necrosis factor-a, interleukin 4, IL- and interleukin 13 (IL-13) in BALF were measured using ELISA method. Differential cytometry of macrophages, lymphocytes, neutrophils and eosinophils were per-formed in 200 cells per slide (one slide per animal) .Lung tissue sections of 6-μm thickness were stained with Mayer’s hematoxylin and eosin for assessment of cell infiltration, mucus production, and tissue damage. Results: Oral admi nistration of amurensin H over inhibited OVA-induced increases in total cell counts, eosinophil counts, and TNF-α, IL-4, IL-5 and IL-13 levels in BALF. and mucus production. Conflusion: Amurensin H may have therapeutic potential for the treatment of allergic airway inflammation.