目的:对比最小漏气法与囊压表法给气管插管气囊注气后的气囊压力和呼吸机漏气量以及患者相关并发症，为临床气管插管患者获得合适的气囊压提供理论依据。方法:采用前瞻性随机对照研究，选择2015年12月至2019年6月天津市第五中心医院重症医学科收治的100例需气管插管机械通气的成人患者。按照随机数字表法将患者分为试验组和对照组，每组50例。气管插管成功后，所有患者均取平卧位，床头抬高30°。试验组应用最小漏气法给气囊注气，并应用气囊测压表获得气囊压力值；对照组应用囊压表法注气使气囊压力达到25～30 cmHn 2O（1 cmHn 2O＝0.098 kPa）。比较两组患者初次充气时（0 h）和充气4 h、8 h气囊压力及呼吸机漏气量等参数，以及患者拔除气管导管后呼吸机相关性肺炎（VAP）及气道并发症的发生情况。n 结果:100例重症患者中男性53例，女性47例；年龄23～87岁，平均（68.53±8.46）岁；气管导管留置时间1～16 d。①两组患者4 h和8 h时气囊压力均较初次充气时降低，呼吸机漏气量均随时间延长逐渐增加。与对照组比较，试验组各时间点气囊压力均明显高于对照组〔mmHg（1 mmHg＝0.133 kPa）：0 h为33.72±9.14比25.68±5.26，4 h为30.54±7.81比24.35±4.93，8 h为26.57±5.64比22.42±4.14，均n P<0.05〕，呼吸机漏气量均小于对照组（mL：0 h为25.57±8.51比34.65±9.47，4 h为40.54±8.51比60.34±7.85，均n P<0.05）。②试验组VAP发生率明显低于对照组（4%比10%，n P0.05）。n 结论:最佳的气囊压力对预防VAP及减少气道并发症十分重要，最小漏气法使临床获得的气管插管气囊压更加精准，漏气量少，且安全有效，值得临床推广。“,”Objective:To compare the cuff pressure and leakage volume and the related complications of filling the tracheal tube cuff by minimum air leakage method and cuff pressure manometer method after endotracheal intubation, so as to provide theoretical basis for patients who was intubated to obtain appropriate cuff pressure.Methods:A prospective randomized controlled study was conducted. 100 patients admitted to the department of critical care medicine of the Fifth Center Hospital in Tianjin from December 2015 to June 2019 were enrolled. According to the random number table method, the patients were divided into the experimental group and control group, with 50 patients in each group. After successful endotracheal intubation, all patients were placed in a supine position with the head of the bed raised by 30°. The experimental group used the minimum air leakage method, and used the cuff pressure manometer to obtain the cuff pressure. In the control group, cuff pressure was maintained at 25-30 cmHn 2O (1 cmHn 2O = 0.098 kPa). Parameters such as cuff pressure and ventilator leakage volume at the beginning and 4 hours, 8 hours after the inflation were compared between the two groups, as well as the incidence of ventilation-associated pneumonia (VAP) and airway complications after extubation.n Results:Among the 100 cases, 53 were males and 47 were females. The age ranged from 23 to 87 years old, with an average of (68.53±8.46) years old. The intubation time ranged from 1 to 16 days.① At 4 hours and 8 hours after inflation, the cuff pressures of the two groups were lower than that of the first time of inflation, and the air leakage of the ventilator increased gradually with the extension of time. Compared with the control group, cuff pressures at each time point in the experimental group were significantly higher than those in the control group [mmHg (1 mmHg = 0.133 kPa): 33.72±9.14 vs. 25.68±5.26 at 0 hour, 30.54±7.81 vs. 24.35±4.93 at 4 hours, 26.57±5.64 vs. 22.42±4.14 at 8 hours, all n P < 0.05], and ventilator leakage volumes were smaller than those in the control group (mL: 25.57±8.51 vs. 34.65±9.47 at 0 hour, 40.54±8.51 vs. 60.34±7.85 at 4 hours, both n P < 0.05). ② The incidence of VAP in the experimental group was significantly lower than that in the control group (4% vs. 10%, n P 0.05).n Conclusions:The optimal cuff pressure is very important for preventing VAP and reducing airway complications. The minimum air leakage method makes the clinical obtained endotracheal intubation cuff pressure more accurately, with less air leakage, safe and effective, and it is worthy of clinical promotion.