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目的:探讨血清睾酮(T)、雌二醇(E2)、皮质醇(Cor)的含量在老年消化性溃疡病程中的变化。方法:用微粒子化学发光免疫分析法分别检测86例老年消化性溃疡活动期、愈合期及78例健康老年人的血清T、E2、Cor的水平。结果:老年消化性溃疡患者活动期血清T、E2比溃疡愈合期和健康老年人明显降低(P<0.01),Cor含量无明显差异(P>0.05)。结论:血清T、E2的浓度变化对老年消化性溃疡的病程和疗效判断有指导意义。
Objective: To investigate the changes of serum testosterone (T), estradiol (E2) and cortisol (Cor) in the course of senile peptic ulcer. Methods: The levels of serum T, E2 and Cor in 86 senile patients with peptic ulcer during active phase, healing phase and 78 healthy elderly were detected by microparticle chemiluminescence immunoassay. Results: The activities of serum T and E2 in elderly patients with peptic ulcer were significantly lower than those in ulcer healing and healthy elderly (P <0.01), while there was no significant difference in Cor content (P> 0.05). Conclusion: The changes of serum T and E2 concentrations have guiding significance for judging the course of disease and curative effect of senile peptic ulcer.