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目的报告医源性肉毒毒素中毒相关的严重不良事件。方法总结分析3例医源性肉毒毒素中毒患者的临床表现特征、治疗和预后等临床资料,并结合文献复习进行讨论。结果 3例女性患者均为美容而局部注射肉毒毒素,于注射后数天内出现吞咽困难、呼吸费力、双眼睑显著下垂、视物模糊、头晕、全身无力等症状。患者入院后经支持治疗后症状缓解,3个月后随访恢复良好。结论应用肉毒毒素治疗或美容可引发严重不良事件。临床医生应熟知治疗肌肉的解剖学和肉毒毒素的药理学特征以避免发生严重不良事件。
Purpose To report serious adverse events related to iatrogenic botulinum toxin poisoning. Methods The clinical features, treatment and prognosis of 3 patients with medical botulinum toxin poisoning were summarized and analyzed. Results All the 3 female patients were treated with botulinum toxin (Botulinum toxin). Some patients suffered from dysphagia within several days after injection, difficulty in breathing, significant drooping of both eyelids, blurred vision, dizziness and general weakness. After admission, the symptoms were relieved after supportive treatment and were followed up after 3 months. Conclusion The treatment of botulinum toxin or cosmetic treatment can lead to serious adverse events. Clinicians should be familiar with the anatomy of muscle treatment and the pharmacological characteristics of botulinum toxin in order to avoid the occurrence of serious adverse events.