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本项研究证实从４～６．５个月的胎儿组织提取的有效成份（简称ＨＦＥ）具有多种生物学活性：可促进受照射损伤的小鼠造血功能的恢复，４项检测指标包括：①骨髓有核细胞数：实验组：６５．５±１５．８，对照组：１６．４±６．２。②外周血网织红细胞百分比Ｘ±ＳＤ，实验组：１６．６±０．６０，对照组０．２±０．０４。③ＣＦＵ－ＳＸ±ＳＤ，实验组：１９．６±９．６６，对照组：１．９±２．２８。④骨髓增生程度：实验组优于对照组。对５个肿瘤细胞株和正常人二倍体细胞株２ＢＳ均有不同程度的抑制生长作用，ＥＤ５０分别为Ｈｅｌａ：６２．５μｇ／ｍｌ，ＭＣＦ－７：７．８μｇ／ｍｌ，ＨＥＰ－２：４μｇ／ｍｌ，ＳＭＭＣ７７２１：６２．５μｇ／ｍｌ，Ｔｅａ：４．５μｇ／ｍｌ，而对ＬＡ－７９５和Ａ－５４９则有轻度刺激作用。可刺激人外周血单个核细胞增殖并与ＰＨＡ，ＩＬ－２有协同作用。对氨甲喋呤引起的大鼠肝、肺损伤有一定的保护治疗作用。本项研究将为其临床应用提供实验依据。
This study confirms that the active ingredients extracted from fetal tissues from 4 to 6.5 months (referred to as HFE) have a variety of biological activity: can promote the recovery of hematopoietic function in mice irradiated by irradiation, four test indicators include: ① The number of bone marrow nucleated cells: experimental group: 65.5 ± 15.8, control group: 16.4 ± 6.2. ② The percentage of reticulocyte in peripheral blood was ± SD, the experimental group was 16.6 ± 0.60, the control group was 0.2 ± 0.04. ③ CFU-SX ± SD, experimental group: 19.6 ± 9.66, control group: 1.9 ± 2.28. ④ degree of myeloproliferation: experimental group than the control group. Growth inhibition was observed in 5 tumor cell lines and normal human diploid cell lines 2BS with ED50 of Hela of 62.5μg / ml, MCF-7 of 7.8μg / ml, HEP-2 of 4μg / Ml, SMMC7721: 62.5 μg / ml, Tea: 4.5 μg / ml, and mild stimulation of LA-795 and A-549. Can stimulate peripheral blood mononuclear cell proliferation and PHA, IL-2 synergistic effect. Methotrexate-induced liver and lung injury in rats have a protective effect. This study will provide experimental evidence for its clinical application.