[目的]观察大黄灌肠+中药热敷联合西药治疗脓毒症疗效。[方法]使用随机平行对照方法,将48例住院患者按就诊顺序号方法简单随机分两组。对照组24例抗感染、控制血糖、营养支持、预防应激性溃疡等基础支持治疗。治疗组24例中药保留灌肠,取药液200mL,加温37℃,体位根据患者依从性,肛管前端涂润滑液,插入直肠10~15cm,使药液徐徐进入直肠,药液注完后捏紧肛门,徐徐拔出肛管,勿使药液流出,保留>0.5h,保留越长时间越好;中药热敷,取与药液同煮后的热毛巾拧干,折叠成约10cm×10cm大小,待温度降至患者能接受温度时轻轻敷于患者神阙处,30min/次,1次/d;西药治疗同对照组。连续治疗7d为1疗程。观测临床症状、补体C3(C3)、补体C4(C3)、C反应蛋白(CRP)、前白蛋白(PA)、白蛋白(ALB)、急性生理与慢性健康评分(APACHEⅡ评分)、不良反应。治疗1疗程,判定疗效。[结果]APACHEⅡ评分疗效组间无明显差异(P>0.05)。C3、C4、CRP、PA、ALB两组均有改善(P<0.05,P<0.01),C3、C4、CRP、ALB治疗组改善均优于对照组(P<0.05,P<0.01);PA组间无明显差异(P>0.05)。[结论]大黄灌肠+中药热敷联合西药治疗脓毒症,疗效满意,改善血液循环,加速体内废物代谢,明显改善急性时相反应蛋白,提高机体免疫力及生存率,从而减低死亡率,值得推广。 [Objective] To observe the curative effect of rhubarb enema + traditional Chinese medicine combined with western medicine on sepsis. [Method] Using randomized parallel control method, 48 inpatients were randomly divided into two groups according to the sequence number of visiting doctor. Control group, 24 cases of anti-infection, blood sugar control, nutritional support, prevention of stress ulcer and other basic supportive treatment. The treatment group, 24 cases of Chinese medicine retention enema, take liquid 200mL, warming 37 ℃, body position according to patient compliance, anal canal front lubricating fluid, inserted into the rectum 10 ~ 15cm, the liquid slowly into the rectum, liquid injection after the pinch Tight anus, slowly pulled out the anal canal, do not make the liquid outflow, retention> 0.5h, retain the longer the better; Chinese hot compress, take the hot towel with the liquid after cooking wrung, folded into about 10cm × 10cm size , Until the temperature dropped to the patient can accept the temperature gently deposited in the patient Shenque Department, 30min / time, 1 / d; western medicine treatment with the control group. Continuous treatment 7d for a course of treatment. The clinical symptoms, C3 (C3), C4 (C3), CRP, ALB, APACHEⅡ score, adverse reactions were observed. Treatment of a course of treatment to determine the efficacy. [Results] There was no significant difference between APACHE Ⅱ score efficacy groups (P> 0.05). The levels of C3, C4, CRP, PA and ALB in both groups were significantly improved (P <0.05, P <0.01). The improvement of C3, C4, CRP and ALB in treatment group was better than that in control group No significant difference between groups (P> 0.05). [Conclusion] rhubarb enema combined with traditional Chinese medicine and heat compress combined with Western medicine in treatment of sepsis has satisfactory curative effect, improves blood circulation, accelerates the metabolism of wastes in body, significantly improves acute phase reaction protein, improves immunity and survival rate of organism, thus reduces mortality and is worth popularizing .