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组蛋白是细胞核内的一种碱性蛋白,它由五种亚单位(H1、H2A、H2B、H3H4)组成。H2A、H2B、H3、H4各两个分子组成八聚体,形成一个核,DNA位于其表面,这就是所谓核小体结构,而H1则与核小体之间的DNA连接区结合。以往对组蛋白的研究主要限于生化方面,认为组蛋白的功能主要是调节DNA复制及转录等。但近年的研究发现组蛋白与免疫也有密切关系,本文主要介绍组蛋白在免疫调节及自身免疫性疾病方面的作用。一、组蛋白与免疫调节激素胸腺激素在免疫调节中的作用已被人们所知,Comsa等很早就分离到一种胸腺激素,称为自稳胸腺激素(Homestatic Th-ymus Hormone,HTH)。HTH的功能有多方面,它可以使胸腺切除的动物恢复产生抗体的能力,另外还有淋巴细胞趋化作
Histone is a basic protein in the nucleus that consists of five subunits (H1, H2A, H2B, H3H4). H2A, H2B, H3, H4 each two molecules form an octamer, forming a nuclear DNA located on its surface, which is the so-called nucleosome structure, and H1 and nucleosome junction region between the DNA binding. In the past, the research on histones was mainly confined to the biochemical aspects. The function of histones was mainly to regulate DNA replication and transcription. However, recent studies have found that histone and immune are also closely related, this article focuses on the role of histone in immune regulation and autoimmune diseases. First, the histone and immunomodulatory hormone thymus hormone in the role of immune regulation has been known, Comsa and so long ago isolated a thymus hormone, called the self-stabilizing thymus hormone (Homestatic Th-ymus Hormone, HTH). HTH has many functions, it can make thymus animals to restore the ability to produce antibodies, in addition to lymphocyte chemotaxis