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四环素类抗生素曾因抗菌谱广,价格低而广泛用于临床。由于长期使用,耐药菌株大大增加,目前临床致病菌大多已产生了四环素耐药性,本文概述其不良反应。1 肾功能障碍 肾功能正常患者服用四环素类药物一般无不良反应。肾功能受损的患者服用四环素类时,可出现氮质血症,血清半衰期延长,血清浓度升高。由于四环素的抗合成代谢作用,可加重氮质血症,使血尿素氮和肌肝升高。此外,还可引起Fanconi’s综合征。临床表现为多尿、烦渴等,严重者可有生命危险。
Tetracycline antibiotics have broad antibacterial spectrum, low price and widely used in clinical. Due to long-term use, drug-resistant strains have greatly increased, most of the current clinical pathogens have produced tetracycline resistance, this article outlines its adverse reactions. 1 renal dysfunction in patients with normal renal function tetracyclines generally no adverse reactions. Patients with impaired renal function taking tetracyclines, there may be azotemia, serum half-life prolongation, serum concentration increased. As tetracycline anabolic effects, can increase azotemia, so that blood urea nitrogen and muscle liver increased. In addition, it can cause Fanconi’s syndrome. Clinical manifestations of polyuria, polydipsia, etc., serious cases can have life-threatening.