川芎嗪是中药川芎中提取的生物碱,化学结构为四甲基吡嗪。药理研究证明是一种新型钙离子拮抗剂,活血化瘀,抗血小板凝集,扩张血管,增强冠脉血流量,改善微循,促进血流的运行及局部微循环的恢复,调节血液流变作用;并有抗病毒及提高组织耐氧能力;保护血管内皮细胞,减少毛细胞管通透性的作用,减轻肺损伤。近年来其临床应用不断拓宽,本文结合文献现综述如下。 Ligustrazine is an alkaloid extracted from Rhizoma Chuanxiong and has the chemical structure of tetramethylpyrazine. Pharmacological studies have proven to be a new type of calcium antagonist, promoting blood circulation, reducing blood stasis, preventing platelet aggregation, dilating blood vessels, enhancing coronary blood flow, improving microcirculation, promoting blood flow, restoring local microcirculation, and regulating hemorheology ; And have anti-virus and improve tissue resistance to oxygen; protect the vascular endothelial cells, reduce hair cell tube permeability, reduce lung injury. In recent years, its clinical application has been continuously broadened. The combined literature is summarized as follows.