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[目的]研究2型糖尿病与脂联素基因SNP+45、SNP+276的相互关系。[方法]采用单因素非条件Logistic回归分析,对上海市浦东新区常住居民中新发糖尿病患者(糖尿病组)及社区正常人群(对照组)各590人进行病例-对照研究。[结果]糖尿病组与对照组比较,脂联素基因SNP+45的3种基因型和等位基因分布的差异无统计学意义(χ2=1.44,P>0.05;χ2=1.35,P>0.05)。脂联素基因SNP+276的3种基因型和等位基因分布的差异有统计学意义(χ2=8.45,P<0.05;χ2=8.99,P<0.05),糖尿病患者T/T基因型多于对照组人群。单因素分析显示,脂联素基因SNP+276与糖尿病的关系有统计学意义。[结论]脂联素基因SNP+276与浦东新区汉族人群2型糖尿病的发病相关,脂联素基因的变异可能在2型糖尿病发病过程中起重要作用。
[Objective] To study the relationship between type 2 diabetes and adiponectin gene SNP + 45, SNP + 276. [Methods] The univariate non-conditional logistic regression analysis was used to conduct a case-control study on 590 new diabetics (DM group) and 590 normal community (control group) residents in Shanghai Pudong New Area. [Results] There was no significant difference in the genotype and allele distribution of adiponectin gene SNP + 45 between diabetic group and control group (χ2 = 1.44, P> 0.05; χ2 = 1.35, P> 0.05) . The genotype and allele distribution of adiponectin gene SNP + 276 were significantly different (χ2 = 8.45, P <0.05; χ2 = 8.99, P <0.05). There were more T / T genotypes in diabetes Control group of people. Univariate analysis showed that the association between adiponectin gene SNP + 276 and diabetes was statistically significant. [Conclusion] Adiponectin gene SNP + 276 is associated with the onset of type 2 diabetes in Han population in Pudong New Area. The variation of adiponectin gene may play an important role in the pathogenesis of type 2 diabetes.