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目的 :观察白细胞介素 - 1 3(IL - 1 3)对肾小球系膜细胞增殖的影响。方法 :应用流式细胞仪检测加入不同浓度 IL - 1 3作用后对肾小球系膜细胞 DNA含量的变化。结果 :各实验组的 DNA合成前期 (G1期 )细胞数增加 ,而合成期 (S期 )细胞数降低 ,各实验组与对照组比较 ,差异均有显著性 (P<0 .0 1 )。结论 :IL - 1 3具有抑制肾小球系膜细胞增殖作用
Objective: To observe the effects of interleukin - 1 (IL - 13) on the proliferation of glomerular mesangial cells. Methods: The changes of DNA content in glomerular mesangial cells were detected by flow cytometry after adding different concentrations of IL - 1 3. Results: The number of cells in the early stage of DNA synthesis (G1 phase) increased and the number of cells in the synthesis phase (S phase) decreased in each experimental group. The differences between the experimental group and the control group were significant (P <0.01). Conclusion: IL - 1 3 can inhibit the proliferation of mesangial cells