大部分肿瘤细胞在氧供充足时,仍会利用糖酵解来产生ATP,这种现象称为瓦伯格效应(Warburg effect)。这种产能效率远低于线粒体氧化磷酸化的代谢方式,其成因和对肿瘤发生发展的作用尚不明确。但科学界普遍认为肿瘤细胞一定从有氧糖酵解中获得生长优势。本文结合本实验室及学术界最新的研究结果,对瓦伯格效应促进生物合成的生化机制进行探讨,并在此基础上提出在葡萄糖充足或缺乏时肿瘤细胞均能维持生长优势的模型。 Most of the tumor cells still use glycolysis to generate ATP when the oxygen supply is sufficient, a phenomenon known as the Warburg effect. This production efficiency is much lower than that of mitochondrial oxidative phosphorylation, its genesis and its role in tumor development is not yet clear. However, the scientific community generally believes that tumor cells must gain growth advantage from aerobic glycolysis. Based on the latest research findings in our laboratory and academia, this paper explores the biochemical mechanisms by which the Waborg Effect promotes biosynthesis. Based on this, we propose a model that supports the growth of tumor cells in glucose-rich or absent-serum conditions.