青春发育与下丘脑对性激素负反馈调节产生反应的敏感性降低及夜间促性腺激素(GTH)波动式分泌有关。后者由 LHRH 脉冲式释放所引起。释放的节律及时间为发挥生物效应的关键。持续应用天然 LHRH 或长效 LHRH 促效剂首先促进,继 Puberty development is associated with decreased sensitivity of the hypothalamus to the negative feedback regulation of sex hormones and fluctuating secretion of gonadotropin (GTH) at night. The latter is caused by the pulsatile release of LHRH. Release rhythm and time to play a biological effect of the key. Continued use of natural LHRH or long-acting LHRH agonists first promote, follow