华氏巨球蛋白血症(Waldenstrm macroglobulinemia,WM)是一种少见的以血清单克隆IgM为主要特征的惰性淋巴细胞肿瘤,其发病率较低,临床表现高度异质,容易引起漏诊和误诊。因此,2016年中国抗癌协会血液肿瘤委员会、中华医学会血液学分会白血病淋巴瘤学组和中国抗淋巴瘤 Waldenstrm macroglobulinemia (WM) is a rare idiopathic lymphoid neoplasm characterized by serum monoclonal IgM, with low incidence and high heterogeneity in clinical manifestations, which may lead to misdiagnosis and misdiagnosis . Therefore, in 2016 China Anti-Cancer Association Hematological Oncology Committee, Chinese Medical Association Hematology Branch leukemia lymphoma group and Chinese anti-lymphoma